Citrus sinensis is rich in phytochemicals such as limonene, β-sitosterol, and ascorbic acid, which possess pharmacological action. In this study, we investigated the role of 50% ethanolic extract of Citrus sinensis on hepatic response of the liver against injury. Liver injury was induced by single intraperitoneal injection of thioacetamide (400 mg/kg b. wt.). Pre-treatment of rats with the extract (800 mg/kg body wt, orally) for three consecutive days significantly ameliorated the changes associated with hepatic injury, particularly the levels serum biochemical markers of liver injury and oxidative stress. The study has implication in human as the animal model of hepatic injury produced by thioacetamide in this study mimics the changes observed in alcohol induced liver injury in human.
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